United Kingdom
The Netherlands, Switzerland, Austria, Italy, Sweden, Denmark, France, Poland
Israel, Greece

Inserm-ERI 23, Poitiers

Inserm-ERI 23, Poitiers (Poitiers)-France
The University of Poitiers (www.univpoitiers.fr
) students, research professors and international research personnel and provides the infrastructure necessary for their complete integration. Several doctoral schools are located in the university: Engineering and Aeronautics, Chemical engineering, humanities Social studies and Economics, Law studies, and Biology and Health. Our research group “Pharmacology of Antiinfectious Agents” is connected to that doctoral school and located at the “Pôle Biologie Santé” that benefits from modern laboratories and equipment for conducting research. As members of the Poitiers University Hospital we can rely on the Center for Clinical Investigations (CIC) which is partly founded by Inserm. Our group also benefits from an Inserm recognition.

Main tasks
Our group will be contributing to the colistin project, in particular plasma protein binding determination using microdialysis.

Previous experience
Our group has gained quite long expertise and international recognition conducting microdialysis studies both in animals and human and we have recently been conducting experiments to investigate colistin pharmacokinetics,starting with the development of a new LCMS/MS assay. For the first time to our knowledge we have used intravenous microdialysis for the assessment of antibiotics protein binding in humans. This approach is the only remaining alternative when other methods such as exvivo equilibrium dialysis or ultrafiltration are not applicable because of drug degradation at 37°C or non specific adsorption on the membranes, as encountered with colistin.Our objective is to investigate colistin protein binding in human using microdialysis.

Key personnel
William Couet (PhD) is Professor of Clinical Pharmacy at the University of Poitiers, School of Medicine and Pharmacy, and Hospital Practitioner at the Poitiers University Hospital. He is also Director of the Inserm ERI23 research group “Pharmacology of Antiinfectious Agents”. Pr W. Couet has published over 90 papers and is member of the Editorial Board of Antimicrobial Agents Chemother. His research interest includes tissue distribution of antibiotics in vitro to investigate the role of active transport systems and in vivo using microdialysis in animals as well as in humans. He is also interested in pharmacokineticpharmacodynamic modelling of antibiotics, with special focus on colistin to treat multidrug resistant Gramnegative bacterial infections.

Recent publications

Download this file (Publications-Couet.pdf)Publications-Couet.pdf[Recent publications W Couet]194 kB