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Radboud University Nijmegen Medical Centre

Radboud University Nijmegen Medical Centre (RUNMC) – The Netherlands
logo UMC nijmegenThe Radboud University Nijmegen Medical Centre (RUNMC) is an important part of the Radboud University and one of the leading academic communities in the Netherlands. Research on infectious diseases in all its aspects is one of the key research areas and is centered in the Nijmegen Institute for Infection, Inflammation and Immunity (N4i). As part of N4i, the Department of Medical Microbiology focuses on several major research areas, including malaria. Clinical mycology is also an important focus, including pharmacodynamics of antimycotic agents and molecular epidemiology. Emergence of resistance is one of the key elements: recently the group described emergence of azole resistance in A. fumigatus for the first time. The department and N4i institute have extensive experience in hospital epidemiology and rational use of antibiotics.

Main tasks
RUNMC is WP‐leader for WP4 and will coordinate the pharmacokinetic and pharmacodynamic studies and perform part of the work. This partner will also contribute to the dissemination activities in WP5. Finally, RUNMC is responsible for WP6 (project management): RUNMC will support the project coordinator in the operational project management tasks and be responsible for the administrative, financial and legal issues.

Previous experience
Several animal infection models were developed and are available for PK/PD studies as well as alternative in PK/PD in vitro models. Recently sensitive qPCR methods have been developed as outcome parameter. There is significant experience in surveillance and epidemiology of resistance as well as rational use of antibiotics. Population pharmaco‐kinetic modeling is one of the new key areas of research for all anti‐infectives. Therapeutic Drug Monitoring of anti‐infectives is performed for both national and international study sites.

RUNMC is involved as partner in many FP6 and FP7 projects and, moreover, has extensive experience in the coordination of FP‐Projects. Johan W. Mouton is a partner and WP leader in the FP7 project SATURN and involved in many collaborative projects and research activities.

Key personnel
Johan W Mouton (MD, PhD) was trained as a medical scientist as well as medical Microbiologist. His research focused on two main areas: epidemiology of resistance and antimicrobial pharmacodynamics. He served as the president of the International Society of Antiinfective Pharmacology and is member of the steering committee of EUCAST (European Committee on Antimicrobial Susceptibility Testing), among other offices. He has published >150 papers in peer‐reviewed scientific journals, among which several collaborative papers to standardize approaches in the field.

Recent publications
Download this file (Publications-Mouton.pdf)Publications-Mouton.pdf[J. Mouton-Publications 2010-2012]120 kB