Most publications on nitrofurantoin focus on adverse events in form of case reports. Few well designed clinical studies and no PK/PD information are available.
Selected publications on nitrofurantoin
Urinary Tract Infections: Current and Emerging Management StrategiesPublication by Barber AE, Norton JP, Spivak AM, Mulvey MA. Clin Infect Dis. 2013 Sep;57(5):719-24.
Nitrofurantoin: Preferred Empiric Therapy for Community-Acquired Lower Urinary Tract Infections
Publication by Cunha BA, Schoch PE, Hage JR. in Mayo Clin Proc. 2011 Dec;86(12):1243-4
Cystitis Treatment in Women, Circa 2011: New Role for an Old Drug
Publication by Schultz HJ, Edson RS.in Mayo Clin Proc. 2011 Jun;86(6):477-9.
Diagnosis and Treatment of Acute Uncomplicated Cystitis
Publication by Colgan R, Williams M. Am Fam Physician. 2011 Oct 1;84(7):771-6.
Uncomplicated Urinary Tract Infections (S3 guidelines for UTIs)
Publication by Wagenlehner FM, Hoyme U, Kaase M, Fünfstück R, Naber KG, Schmiemann G. Dtsch Arztebl Int. 2011 Jun;108(24):415-23.
Antimicrobial agents for treating uncomplicated urinary tract infection in women. Cochrane review.
Publication by Zalmanovici Trestioreanu A, Green H, Paul M, Yaphe J, Leibovici L. in Cochrane Database Syst Rev. 2010 Oct 6;(10):CD007182