At a glance
- Class: rifamycin; blocks bacterial RNA production.
- Its activity spans certain bacteria, but it is not a universal antibiotic.
- Often supplied as oral capsules or liquid; other forms exist by region.
- It can reduce the effectiveness of some medicines, including some contraception.
What it is and how it works
Rifampicin blocks bacterial RNA polymerase, interrupting the production of essential RNA. It has a specific role in treatment regimens, including tuberculosis care, and is sometimes combined with other medicines for other specialist indications.
Resistance can develop quickly in some settings if rifampicin is used inappropriately. Treatment decisions belong with the clinical team.
Forms, effects and interactions
Rifampicin is commonly available as oral capsules or liquid. It can turn urine, sweat and tears orange-red; nausea and other effects can occur. Liver problems and serious reactions require prompt professional assessment.
It can alter how other medicines work, including certain hormonal contraceptives. Discuss all medicines, supplements and contraception with your pharmacist or prescriber before and during treatment.
Historical context
The former AIDA project included research on minocycline with rifampicin for complicated skin and soft-tissue infections. This does not mean that combination is appropriate for any reader.
Follow the medicine-specific instructions you have been given and ask your clinical team about any concerns.
Sources
Original references- NHS · Rifampicin
- NHS · Antibiotic interactions
- European Commission CORDIS · AIDA project record (278348)
- WHO · Antimicrobial resistance
These sources informed this overview. Their organisations do not endorse or review this website.
This page is for general education only. It does not replace advice from a doctor, pharmacist or other qualified healthcare professional. Read our medical disclaimer.