At a glance
- Class: polymyxin antibiotic; acts on the outer membrane of certain bacteria.
- Spectrum: mainly some Gram-negative bacteria, but resistance can occur.
- Forms and uses depend on formulation and country; specialist oversight is important.
- Kidney and nervous-system effects are among important cautions.
What is it and how does it work?
Colistin disrupts the outer membrane of certain Gram-negative bacteria. The colistimethate formulation is converted in the body to active colistin. It is generally considered in specialist care for serious infections when options are limited.
It does not treat viruses, and a bacterium’s susceptibility needs professional interpretation.
Forms, uses and cautions
Colistimethate is commonly administered intravenously in hospital; some formulations may be used by inhalation under specialist direction. Treatment depends on the infection and local product information. Kidney function and other medicines may need monitoring.
Potential effects include kidney problems and neurological effects. Report unexpected symptoms to the treating team. Do not use this page as a dosing or treatment guide.
Resistance and historical context
Colistin’s role in difficult-to-treat infections makes careful stewardship important. The former AIDA project studied colistin in one of its clinical research areas; that historical connection does not imply a recommendation by this independent site.
Sources
Original references- MedlinePlus · Colistimethate injection
- European Commission CORDIS · AIDA project record (278348)
- NHS · Antibiotics overview
- WHO · Antimicrobial resistance
These sources informed this overview. Their organisations do not endorse or review this website.
This page is for general education only. It does not replace advice from a doctor, pharmacist or other qualified healthcare professional. Read our medical disclaimer.